Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.
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However, the implications of this phenomenon, when the drugs are administered topically remain a question to be addressed in future studies.
It is usually used to treat infections with anaerobic bacteria, but can also be used to treat some protozoal diseases, such as malaria.
znd Microemulsions-potential carrier for improved drug delivery. The study revealed that the formulation with carbopol shown better release profile than HPMC K4M, depicting carbopol as the better choice of polymer for aceclofenac emulgel.
On the contrary, in the placebo group inflammation persisted till the 4th h and later showed a decline which was statistically insignificant compared to the treated groups, which reinstates the efficacy of aceclofenac, lack of any activity attributed to excipients and effective delivery of the drug. In this study, polymer-based emulgel formulation of aceclofenac with a microemulsion base was developed and assessed for its anti-inflammatory activity.
The animal studies were conducted in the animal house, under appropriate care and precautions.
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The study was commenced after the relevant approvals from the concerned authorities as well as the animal ethics committee. Versions Version 1 All other chemicals and solvents were of analytical reagent grade. The microemulsion region obtained in 1: Undesirable skin changes, i.
In vitro diffusion studies were done with the help formullation modified Franz diffusion cell Sumati sales corporation, Mumbai, India. Formulation, development and evaluation of emulgel: Saturation solubility of aceclofenac in various oils, surfactants, co-surfactants was determined by saturation solubility method. The percentage change in inflammation was calculated by the same formula as mentioned above.
Most remarkable finding was that the anti-inflammatory activity exhibited by aceclofenac microemulsion-based emulgel. Thus, the microemulsion base improved the solubility of the drug and the emulgel formulation enhanced the delivery in a sustained manner. How to cite this article: An effective anti-inflammatory drug is purported to act via both the pathways, thus mitigating inflammation. Commercially available Terbinafine hydrochloride cream was used for comparison.
Thus, the study was conducted to develop novel microemulsion-based emulgel formulafion of aceclofenac, a poorly water soluble drug and evaluate its anti-inflammatory activity. A similar effect was observed with the marketed diclofenac formulation, which reinforces the proof of efficiency of the marketed gel in delivering diclofenac and reducing inflammation. Although, the pharmacological evidence presented herein, shows a quantitatively higher activity for the marketed preparation, the designed formulation was at par with the marketed one with significantly better activity demonstrated against the placebo.
Formulation and evaluation of oxiconazole emulgel for topical drug delivery
Herein, no further evaluation and animal studies were done to assess the implications of the formulation in vivo. The microemulsion when diluted in 1: It combines dual release pattern of both gel and emulsion providing better therapeutic action and sustained release 34.
Drugs are administered topically for their action at the site of application or for systemic effects. To overcome this limitation, emulgel, a novel drug delivery has emerged which is a combination of gel and emulsion, where the presence of gelling agent in the water phase converts a classical emulsion into a gel. These results were concordant with the study conducted by Fathalla et al.
It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus MRSA infections. In both the models, the inflammatory edema reached its maximum level at the 4h and later started declining. The emulgel was applied on the properly shaven skin of rat.
Hence, the study yields valuable insights into improving the solubility of a BCS class II drug, through a microemulsion based emulgel. The solubilization capability of aceclofenac in different oils, surfactant and co surfactant was shown in the Table 1.
Search in Google Scholar. Formulation and evaluation of oxiconazole emulgel for topical drug delivery Author: After a number of trials, microemulsion of aceclofenac was optimized with:. However, side effects such as gastric ulcerogenicity, flatulence, indigestion and nausea, limit the utility of oral aceclofenac 1.
Formulation and Evaluation of Tioconazole Emulgel for Topical Drug Delivery System
The in vitro drug release of emulgel was found to be February 21, ; Accepted: This DOI represents all versions, and will always resolve to the latest one. Aceclofenac is a non-steroidal anti-inflammatory drug used for pain relief and inflammation in certain joint disorders. Carrageenan induced paw edema and croton ear edema model. Most read articles by the same author s S.